genetic mutation

noun

plural genetic mutations
: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes
Lacking working copies of the p53 gene, cells can begin to divide without check, though several other genetic mutations are thought to be needed to foster a full-blown malignancy.Natalie Angier

Examples of genetic mutation in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Researchers also introduced a genetic mutation that allowed some synthetic cells to grow faster than others. Greg Wehner, FOXNews.com, 3 July 2026 Researchers are now identifying causes that were invisible before, from noise exposure habits to rare genetic mutations. Allison Palmer, Miami Herald, 1 July 2026 Dylan’s older brother, 9-year-old Ethan Oman, was born with a rare genetic mutation that causes seizures and global developmental delay. Lillian Ashworth, Oc Register, 29 June 2026 In hindsight, researchers said, finding similar genetic mutations in cat and human cancers makes sense. Kyle Melnick The Washington Post, Arkansas Online, 21 June 2026 See All Example Sentences for genetic mutation

Word History

First Known Use

1915, in the meaning defined above

Time Traveler
The first known use of genetic mutation was in 1915

Browse Nearby Words

Cite this Entry

“Genetic mutation.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/genetic%20mutation. Accessed 5 Jul. 2026.

Medical Definition

genetic mutation

noun
: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes
Gaucher's disease results from one of many genetic mutations that can either slow or prevent the breakdown of certain glycolipids, which accumulate in storage vesicles and eventually kill cells.Joseph Alper
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!

More from Merriam-Webster